Title : Indole conjugated silica and magnetic nanoparticles as inhibitors of HIF.

Pub. Date : 2014 Feb 1

PMID : 24184535






1 Functional Relationships(s)
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1 SiO2@indol-IL can inhibit the proliferation of HepG-2 cells in 48 h. Fe3O4@indol-IL can mimic the function of catalase to disproportionate H2O2 to O2, and has obvious effect on the proliferation of HepG-2 cells in 72 h. Moreover, the two nanoparticles show some inhibition on the expression of hypoxia inducible factor (HIF-1alpha), glucose transporter (GLUT1) and the production of lactate in HepG-2 cells. ferryl iron catalase Homo sapiens