Pub. Date : 2014 Jan
PMID : 24172910
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Lapatinib alters the malignant phenotype of osteosarcoma cells via downregulation of the activity of the HER2-PI3K/AKT-FASN axis in vitro. | Lapatinib | AKT serine/threonine kinase 1 | Homo sapiens |
| 2 | Western blotting showed that lapatinib suppressed the activity of HER2-PI3K/AKT-FASN in U2-OS and MG-63 cells in vitro. | Lapatinib | AKT serine/threonine kinase 1 | Homo sapiens |
| 3 | These results suggest that lapatinib may alter the malignant phenotype of OS cells via downregulation of the activity of the HER2-PI3K/AKT-FASN signaling pathway in vitro. | Lapatinib | AKT serine/threonine kinase 1 | Homo sapiens |