Title : PI3 kinase directly phosphorylates Akt1/2 at Ser473/474 in the insulin signal transduction pathway.

Pub. Date : 2014 Jan

PMID : 24169049






1 Functional Relationships(s)
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1 Insulin-induced GLUT4 translocation to the cell surface was prevented by the phosphoinositide 3 kinase (PI3K) inhibitor wortmannin, the 3-phosphoinositide-dependent protein kinase 1 (PDK1) inhibitor BX912 or the Akt1/2 inhibitor MK2206, and by knocking-down PI3K, PDK1 or Akt1/2. Wortmannin solute carrier family 2 member 4 Homo sapiens