Title : Mechanisms for luteinizing hormone induction of growth hormone gene transcription in fish model: crosstalk of the cAMP/PKA pathway with MAPK-and PI3K-dependent cascades.

Pub. Date : 2014 Feb 15

PMID : 24161589






2 Functional Relationships(s)
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1 GH promoter activation induced by hCG occurred with concurrent rise in cAMP production, CREB phosphorylation, and could be inhibited by inactivation of adenylate cyclase (AC), PKA, MEK1/2, P(38) MAPK, PI3K and mTOR. Cyclic AMP hypertrichosis 2 (generalised, congenital) Homo sapiens
2 AC activation, presumably via cAMP production, could mimic hCG-induced CREB phosphorylation and GH promoter activity, and these stimulatory effects were also sensitive to the blockade of PKA-, MAPK- and PI3K- dependent cascades. Cyclic AMP hypertrichosis 2 (generalised, congenital) Homo sapiens