Title : Celastrol inhibits lipopolysaccharide-induced angiogenesis by suppressing TLR4-triggered nuclear factor-kappa B activation.

Pub. Date : 2014

PMID : 24157922






2 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Celastrol significantly downregulated LPS-induced TLR4 expression and inhibited LPS-induced VEGF secretion in LP-1 cells. celastrol vascular endothelial growth factor A Homo sapiens
2 VEGF levels decreased by 64.8, 84.4 and 92.9% after coexposure to celastrol at 0.025, 0.05 and 0.1 muM, respectively, compared to LPS alone. celastrol vascular endothelial growth factor A Homo sapiens