Title : The sulfamide moiety affords higher inhibitory activity and oral bioavailability to a series of coumarin dual selective RAF/MEK inhibitors.

Pub. Date : 2013 Dec 1

PMID : 24157370






2 Functional Relationships(s)
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1 The sulfamide moiety affords higher inhibitory activity and oral bioavailability to a series of coumarin dual selective RAF/MEK inhibitors. fusarubin zinc fingers and homeoboxes 2 Homo sapiens
2 Introducing a sulfamide moiety to our coumarin derivatives afforded enhanced Raf/MEK inhibitory activity concomitantly with an acceptable PK profile. fusarubin zinc fingers and homeoboxes 2 Homo sapiens