Title : DHT and IGF-1 in peripheral blood lymphocytes: new markers for the biological passport of athletes.

Pub. Date : 2013 Jul-Sep

PMID : 24152843






2 Functional Relationships(s)
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1 First, to obtain a gene signature, we treated cultures of lymphocytes from sedentary males with three doses of 0.237 microg/ml DHT, each of which is 80-fold the physiological concentration in young adult male serum, at days 0, 2 and 4, or with a single dose of 1.25 microg/ml IGF-1, which is 5-fold the physiological concentration in young adult male serum. Dihydrotestosterone insulin like growth factor 1 Homo sapiens
2 We identified six (IDO1, CXCL13, CCL1, GZMB, VDR and IL2RA) and two (FN1 and RAB31) genes that were up-regulated in lymphocytes from sedentary subjects after 7 days of DHT and IGF-1 treatment, respectively. Dihydrotestosterone insulin like growth factor 1 Homo sapiens