Title : Diabetes impairs an interleukin-1β-dependent pathway that enhances neurite outgrowth through JAK/STAT3 modulation of mitochondrial bioenergetics in adult sensory neurons.

Pub. Date : 2013 Oct 24

PMID : 24152426






1 Functional Relationships(s)
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1 Cultured neurons derived from STZ-diabetic mice were treated for 24 hr with IL-1beta and maximal oxygen consumption rate and spare respiratory capacity, both key measures of bioenergetic fidelity that were depressed in diabetic compared with control neurons, were enhanced 2-fold. Streptozocin interleukin 1 beta Mus musculus