Pub. Date : 2013
PMID : 24147174
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Glyburide treatment did not affect glucose levels but was associated with reduced pulmonary cellular influx, reduced bacterial dissemination to both liver and spleen and reduced IL1beta production when compared to untreated controls. | Glyburide | interleukin 1 beta | Mus musculus |
| 2 | Glyburide directly reduced the secretion of IL1beta by BMDMs in a dose-dependent fashion. | Glyburide | interleukin 1 beta | Mus musculus |
| 3 | We further show, for the first time in any model of sepsis, that glyburide acts as an anti-inflammatory agent by reducing IL1beta secretion accompanied by diminished cellular influx and reduced bacterial dissemination to distant organs. | Glyburide | interleukin 1 beta | Mus musculus |