Title : Protective effects of zonisamide against rotenone-induced neurotoxicity.

Pub. Date : 2013 Dec

PMID : 24142350






1 Functional Relationships(s)
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1 Similarly to ZNS effects, the treatment with N-acetyl-cysteine (100 muM) displayed significant protective effects against rotenone-induced ROS production and Deltapsim at 4 and 12 h respectively, reaching the maximal extent at 24 h. Additionally, ZNS displayed antiapoptotic effects, as demonstrated by flow cytometric analysis of annexin V/propidium iodide double staining, and significant attenuated rotenone-increased caspase 3 activity. Propidium latexin Homo sapiens