Title : Haeme oxygenase activity protects the host against excessive cardiac inflammation during experimental Trypanosoma cruzi infection.

Pub. Date : 2014 Jan

PMID : 24140555






1 Functional Relationships(s)
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1 In mice with two different genetic backgrounds, the pharmacologic inhibition of HO activity with zinc-protoporphyrin IX (ZnPPIX) induced enhanced myocarditis and reduced parasitaemia, which was accompanied by an amplified production of nitric oxide and increased influx of CD4(+), CD8(+) and IFN-gamma(+) cells to the myocardium in comparison with the control group. zinc protoporphyrin interferon gamma Mus musculus