Title : Highly expressed cytoplasmic FcεRIβ in human mast cells functions as a negative regulator of the FcRγ-mediated cell activation signal.

Pub. Date : 2014 Feb

PMID : 24118172






2 Functional Relationships(s)
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1 However, overexpression of FcepsilonRIbeta in MCs resulted in down-regulation of the tyrosine phosphorylation levels of FcepsilonRIbeta and Syk and down-regulation of the Ca(2+) influx soon after FcepsilonRI aggregation and then resulted in down-regulation of degranulation, PGD2 synthesis, and production of a set of cytokines. Tyrosine membrane spanning 4-domains A1 Homo sapiens
2 However, overexpression of FcepsilonRIbeta in MCs resulted in down-regulation of the tyrosine phosphorylation levels of FcepsilonRIbeta and Syk and down-regulation of the Ca(2+) influx soon after FcepsilonRI aggregation and then resulted in down-regulation of degranulation, PGD2 synthesis, and production of a set of cytokines. Tyrosine membrane spanning 4-domains A1 Homo sapiens