Title : Activation of signaling pathways downstream of the brain-derived neurotrophic factor receptor, TrkB, in the rat brain by vagal nerve stimulation and antidepressant drugs.

Pub. Date : 2014 Feb

PMID : 24103847






2 Functional Relationships(s)
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1 Previously, chronic administration of VNS to rats was found to phosphorylate tyrosine 515 on TrkB, the neurotrophin receptor, whereas traditional antidepressants did not do this. Tyrosine neurotrophic receptor tyrosine kinase 2 Rattus norvegicus
2 In the present study, Western blot analysis was used to characterize activation due to phosphorylation in the hippocampus of down-stream pathways linked to specific key tyrosine residues on TrkB (namely Y816 and Y515) after either acute or chronic administration of VNS and traditional antidepressant drugs. Tyrosine neurotrophic receptor tyrosine kinase 2 Rattus norvegicus