Title : Can recombinant human glutathione peroxidase 1 with high activity be efficiently produced in Escherichia coli ?

Pub. Date : 2014 Mar 20

PMID : 24093966






2 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Cys residues in hGPx1 were mutated to Ser in turn because untargeted substitution of Sec in place of Cys resulted in the decline of recombinant selenoenzyme activity. Serine glutathione peroxidase 1 Homo sapiens
2 Seleno-hGPx1-C2/78/115/156/202S with all Cys residues changed to Ser showed the highest activity (21,268 U/mumol), which was more than 10-fold higher than bovine liver GPx. Serine glutathione peroxidase 1 Homo sapiens