Title : Antiplatelet effects of caffeic acid due to Ca(2＋) mobilizationinhibition via cAMP-dependent inositol-1, 4, 5-trisphosphate receptor phosphorylation.

Pub. Date : 2014

PMID : 24088646






2 Functional Relationships(s)
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1 RESULTS: CAFA dose-dependently inhibited collagen-induced platelet aggregation and suppressed the production of TXA2, an aggregation-inducing autacoid associated with the strong inhibition of COX-1 in platelet microsomes exhibiting cytochrome C reductase activity. caffeic acid prostaglandin-endoperoxide synthase 1 Rattus norvegicus
2 We demonstrate that CAFA increases cAMP and subsequently phosphorylates both IP3R and VASP-Ser(157) through A-kinase activation to inhibit [Ca(2+)]i mobilization and TXA2 production via the inhibition of the COX-1 activity. caffeic acid prostaglandin-endoperoxide synthase 1 Rattus norvegicus