Pub. Date : 2013
PMID : 24086526
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Sorafenib sensitizes solid tumors to Apo2L/TRAIL and Apo2L/TRAIL receptor agonist antibodies by the Jak2-Stat3-Mcl1 axis. | Sorafenib | signal transducer and activator of transcription 3 | Homo sapiens |
| 2 | We found that sorafenib inhibits Jak/Stat3 signaling and downregulates their target genes, including cyclin D1, cyclin D2 and Mcl-1, in a dose-dependent manner. | Sorafenib | signal transducer and activator of transcription 3 | Homo sapiens |
| 3 | Our findings demonstrate the involvement of the Jak2-Stat3-Mcl1 axis in response to sorafenib treatment, which may play a key role in sorafenib-mediated sensitization to Apo2L/TRAIL. | Sorafenib | signal transducer and activator of transcription 3 | Homo sapiens |
| 4 | Our findings demonstrate the involvement of the Jak2-Stat3-Mcl1 axis in response to sorafenib treatment, which may play a key role in sorafenib-mediated sensitization to Apo2L/TRAIL. | Sorafenib | signal transducer and activator of transcription 3 | Homo sapiens |