Pub. Date : 2014 Jan 1
PMID : 24081156
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The astroglial current is composed of three components sensitive to neuronal activity, i.e. a long-lasting potassium current mediated by Kir4.1 channels, a transient glutamate transporter current and a slow residual current, partially mediated by GABA transporters and Kir4.1-independent potassium channels. | Potassium | potassium inwardly-rectifying channel, subfamily J, member 10 | Mus musculus |
| 2 | As Kir4.1 channel-mediated potassium uptake contributes to 80% of the synaptically evoked astroglial current, we investigated in turn its impact on short-term synaptic plasticity. | Potassium | potassium inwardly-rectifying channel, subfamily J, member 10 | Mus musculus |
| 3 | Using glial conditional Kir4.1 knockout mice, we found that astroglial potassium uptake reduces synaptic responses to repetitive stimulation and post-tetanic potentiation. | Potassium | potassium inwardly-rectifying channel, subfamily J, member 10 | Mus musculus |
| 4 | These results show that astrocytes integrate synaptic activity via multiple ionic channels and transporters and contribute to short-term plasticity in part via potassium clearance mediated by Kir4.1 channels. | Potassium | potassium inwardly-rectifying channel, subfamily J, member 10 | Mus musculus |