Title : Identification and analysis of CD133(+) melanoma stem-like cells conferring resistance to taxol: An insight into the mechanisms of their resistance and response.

Pub. Date : 2014 Feb 1

PMID : 24080340






2 Functional Relationships(s)
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1 In the CD133(-) subpopulation, the exposure to taxol induced the activation of apoptosis signal-regulating kinase1 (ASK1)/c-jun-N-terminal kinase (JNK), p38, extracellular signal regulated kinase (ERK) pathways and Bax expression, while in CD133(+) cells taxol was able only to enhance the activity of the ERK pathway. Paclitaxel BCL2 associated X, apoptosis regulator Homo sapiens
2 In CD133(+) cells, the direct gene transfer of Bax overcame the acquired resistance to taxol. Paclitaxel BCL2 associated X, apoptosis regulator Homo sapiens