Title : Crucial role of Toll-like receptors in the zinc/nickel-induced inflammatory response in vascular endothelial cells.

Pub. Date : 2013 Dec 15

PMID : 24080332






2 Functional Relationships(s)
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1 Following screening of fifteen metals, zinc and nickel were identified with a marked proinflammatory effect, as determined by ICAM-1 and IL-8 induction, on human umbilical vein endothelial cells (HUVECs). Nickel intercellular adhesion molecule 1 Homo sapiens
2 Blockage of TLR-4 signaling by CLI-095, a TLR-4 inhibitor, completely inhibited the nickel-induced ICAM-1 and IL-8 expression and NFkappaB activation. Nickel intercellular adhesion molecule 1 Homo sapiens