Title : Increased efflux of amyloid-β peptides through the blood-brain barrier by muscarinic acetylcholine receptor inhibition reduces pathological phenotypes in mouse models of brain amyloidosis.

Pub. Date : 2014

PMID : 24072071






2 Functional Relationships(s)
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1 Here we show that oral treatment with ACI-91 (Pirenzepine) dose-dependently reduced brain Abeta burden in AbetaPPPS1, hAbetaPPSL, and AbetaPP/PS1 transgenic mice. Pirenzepine presenilin 1 Mus musculus
2 Here we show that oral treatment with ACI-91 (Pirenzepine) dose-dependently reduced brain Abeta burden in AbetaPPPS1, hAbetaPPSL, and AbetaPP/PS1 transgenic mice. Pirenzepine presenilin 1 Mus musculus