Pub. Date : 2013 Dec
PMID : 24071474
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Ursolic acid induces apoptosis of SW480 cells via p53 activation. | ursolic acid | tumor protein p53 | Homo sapiens |
| 2 | Both the expression level and transcriptional activity of p53, an apoptotic protein, were remarkably up-regulated in cells treated with ursolic acid compared to blank group. | ursolic acid | tumor protein p53 | Homo sapiens |
| 3 | Above results demonstrate that ursolic acid induces the activation of p53, NF-kappaB and Bax, leading to the enhancement of p21 transcriptional activity and activation of Caspase-9 and -3, thus finally induces apoptosis of SW480 cells. | ursolic acid | tumor protein p53 | Homo sapiens |