Title : p53 increases caspase-6 expression and activation in muscle tissue expressing mutant huntingtin.

Pub. Date : 2014 Feb 1

PMID : 24070868






4 Functional Relationships(s)
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1 Using mouse embryonic fibroblasts (MEFs) from YAC128 mice, we show that this increase in caspase-6 activity can be mitigated by pifithrin-alpha (pifalpha), an inhibitor of p53 transcriptional activity, but not through the inhibition of p53"s mitochondrial pro-apoptotic function. pifithrin transformation related protein 53, pseudogene Mus musculus
2 Using mouse embryonic fibroblasts (MEFs) from YAC128 mice, we show that this increase in caspase-6 activity can be mitigated by pifithrin-alpha (pifalpha), an inhibitor of p53 transcriptional activity, but not through the inhibition of p53"s mitochondrial pro-apoptotic function. pifithrin transformation related protein 53, pseudogene Mus musculus
3 Using mouse embryonic fibroblasts (MEFs) from YAC128 mice, we show that this increase in caspase-6 activity can be mitigated by pifithrin-alpha (pifalpha), an inhibitor of p53 transcriptional activity, but not through the inhibition of p53"s mitochondrial pro-apoptotic function. pifithrin transformation related protein 53, pseudogene Mus musculus
4 Using mouse embryonic fibroblasts (MEFs) from YAC128 mice, we show that this increase in caspase-6 activity can be mitigated by pifithrin-alpha (pifalpha), an inhibitor of p53 transcriptional activity, but not through the inhibition of p53"s mitochondrial pro-apoptotic function. pifithrin transformation related protein 53, pseudogene Mus musculus