Pub. Date : 2013 Sep 26
PMID : 24066967
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Recent advances in our understanding of the structure and function of deoxycytidine kinase (dCK), a critical enzyme required for the anti-tumor activity for many nucleoside analogs, have clarified the mechanistic role this kinase plays in chemo- and radio-sensitization. | Nucleosides | Calcium/calmodulin-dependent protein kinase II | Drosophila melanogaster |
| 2 | Since most currently employed nucleoside analogs are primarily activated by dCK, these findings lend fresh impetus to efforts focused on profiling and modulating dCK expression and activity in tumors. | Nucleosides | Calcium/calmodulin-dependent protein kinase II | Drosophila melanogaster |
| 3 | Since most currently employed nucleoside analogs are primarily activated by dCK, these findings lend fresh impetus to efforts focused on profiling and modulating dCK expression and activity in tumors. | Nucleosides | Calcium/calmodulin-dependent protein kinase II | Drosophila melanogaster |
| 4 | In this review we will briefly review the pharmacology and biochemistry of the major nucleoside analogs in clinical use that are activated by dCK. | Nucleosides | Calcium/calmodulin-dependent protein kinase II | Drosophila melanogaster |