Title : Enhanced brain delivery of deferasirox-lactoferrin conjugates for iron chelation therapy in neurodegenerative disorders: in vitro and in vivo studies.

Pub. Date : 2013 Dec 2

PMID : 24063264






1 Functional Relationships(s)
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1 Herein, deferasirox, a high affinity iron chelator, was conjugated to lactoferrin molecules by carbodiimide mediated coupling reaction to create a novel drug delivery system with higher brain permeability through receptor mediated transcytosis. Carbodiimides lactotransferrin Rattus norvegicus