Title : Polyunsaturated fatty acyl-coenzyme As are inhibitors of cholesterol biosynthesis in zebrafish and mice.

Pub. Date : 2013 Nov

PMID : 24057001






1 Functional Relationships(s)
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1 First, we found that mutant livers accumulate multiple polyunsaturated fatty acids (PUFAs) and PUFA-CoAs, and we showed that human HMGCR is inhibited by PUFA-CoAs in vitro. Fatty Acids, Unsaturated 3-hydroxy-3-methylglutaryl-CoA reductase Homo sapiens