Title : Effects of 4-alkyl analogues of 3,5-diethoxycarbonyl-1,4-dihydro-2,4,6-trimethylpyridine on hepatic cytochrome P-450 heme, apoproteins, and catalytic activities following in vivo administration to rats.

Pub. Date : 1990 Jan

PMID : 2405248






1 Functional Relationships(s)
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1 Various 4-alkyl analogues of 3,5-diethoxycarbonyl-1,4-dihydro-2,4,6-trimethylpyridine (DDC) cause mechanism-based inactivation of cytochrome P-450 (P-450) via heme destruction. Zalcitabine cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus