Title : Leptin stimulates neuropeptide Y and cocaine amphetamine-regulated transcript coexpressing neuronal activity in the dorsomedial hypothalamus in diet-induced obese mice.

Pub. Date : 2013 Sep 18

PMID : 24048859






5 Functional Relationships(s)
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1 Surprisingly, electrophysiological experiments demonstrated that leptin directly depolarized and increased the firing rate of DMH NPY neurons in DIO mice. 1,2-Dimethylhydrazine neuropeptide Y Mus musculus
2 Importantly, we also demonstrated that DMH NPY neurons coexpress cocaine amphetamine-regulated transcript (CART); however, CART mRNA expression in the DMH peaked earlier in the progression of DIO. 1,2-Dimethylhydrazine neuropeptide Y Mus musculus
3 First, NPY and CART are coexpressed in the same neurons within the DMH, and second, leptin stimulates DMH NPY neurons. 1,2-Dimethylhydrazine neuropeptide Y Mus musculus
4 First, NPY and CART are coexpressed in the same neurons within the DMH, and second, leptin stimulates DMH NPY neurons. 1,2-Dimethylhydrazine neuropeptide Y Mus musculus
5 These studies suggest that during the progression of DIO, there is an unknown signal that drives the expression of the orexigenic NPY signal within the DMH, and that the chronic hyperleptinemia increases the activity of these NPY/CART neurons. 1,2-Dimethylhydrazine neuropeptide Y Mus musculus