Title : AMP-activated protein kinase as a promoting factor, but complement and thrombin as limiting factors for acquisition of cytoprotection: implications for induction of accommodation.

Pub. Date : 2013 Nov

PMID : 24047401






1 Functional Relationships(s)
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1 AMP-activated protein kinase (AMPK) activators such as resveratrol, AICAR and metformin protected endothelial cells against complement-mediated cytotoxicity through the increase in CD55, CD59, haem oxygenase-1 (HO-1) and ferritin heavy chain (ferritin H) genes, all of which were attenuated by AMPKalpha knock-down. Metformin CD59 molecule (CD59 blood group) Homo sapiens