Title : Synthesis of conformationally constrained γ-D-glutamyl-meso-diaminopimelic acid derivatives as ligands of nucleotide-binding oligomerization domain protein 1 (Nod1).

Pub. Date : 2013 Nov

PMID : 24044936






1 Functional Relationships(s)
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1 To gain additional insight into the structure/activity relationships of Nod1 agonistic compounds, a series of novel, conformationally constrained gamma-D-glutamyl-meso-diaminopimelic acid (iE-DAP) analogs have been designed and synthesized. N(2)-(gamma-D-glutamyl)-meso-2,2'-diaminopimelic acid death associated protein Homo sapiens