Title : The natural product dihydrotanshinone I provides a prototype for uncharged inhibitors that bind specifically to the acetylcholinesterase peripheral site with nanomolar affinity.

Pub. Date : 2013 Oct 22

PMID : 24040835






1 Functional Relationships(s)
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1 A potential long-term strategy for preventing AChE inactivation by OPs is based on evidence that OPs must pass through a peripheral site or P-site near the mouth of the AChE active site gorge before reacting with a catalytic serine in an acylation site or A-site at the base of the gorge. Serine acetylcholinesterase (Cartwright blood group) Homo sapiens