Title : Ca2+ /calmodulin-dependent protein kinase II in spinal dorsal horn contributes to the pain hypersensitivity induced by γ-aminobutyric acid type a receptor inhibition.

Pub. Date : 2013 Nov

PMID : 24038144






1 Functional Relationships(s)
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1 We found that pharmacological removal of inhibition by intrathecal application of the GABAA R antagonist bicuculline significantly enhanced the autophosphorylation of CaMKII at Thr286 in spinal dorsal horn of mice. Bicuculline gamma-aminobutyric acid (GABA) A receptor, subunit gamma 2 Mus musculus