Pub. Date : 2014 Mar
PMID : 24037783
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Treatment of cultured spinal astrocytes with isoproterenol (a beta-adrenergic receptor agonist; 1 microM) reduced both TNF-alpha-induced JNK1 phosphorylation, as observed by Western blotting, and the subsequent increase of both CCL2 mRNA expression and CCL2 production, which were measured by real time-PCR and ELISA, respectively. | Isoproterenol | tumor necrosis factor | Homo sapiens |
| 2 | Moreover, treatment with isoproterenol markedly suppressed the TNF-alpha-induced increase of CCL2 mRNA expression and CCL2 production through a beta-adrenergic receptor-PKA pathway mediated by GSK-3beta regulation. | Isoproterenol | tumor necrosis factor | Homo sapiens |