Title : Fatty acid labeling from glutamine in hypoxia can be explained by isotope exchange without net reductive isocitrate dehydrogenase (IDH) flux.

Pub. Date : 2013 Oct 25

PMID : 24030823






2 Functional Relationships(s)
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1 Recent studies have employed isotope tracers to show that in cancer cells grown in hypoxia or with defective mitochondria, a major fraction of acetyl-CoA is produced via another route, reductive carboxylation of glutamine-derived alpha-ketoglutarate (catalyzed by reverse flux through isocitrate dehydrogenase, IDH). Acetyl Coenzyme A isocitrate dehydrogenase (NADP(+)) 1 Homo sapiens
2 Recent studies have employed isotope tracers to show that in cancer cells grown in hypoxia or with defective mitochondria, a major fraction of acetyl-CoA is produced via another route, reductive carboxylation of glutamine-derived alpha-ketoglutarate (catalyzed by reverse flux through isocitrate dehydrogenase, IDH). Acetyl Coenzyme A isocitrate dehydrogenase (NADP(+)) 1 Homo sapiens