Title : Smac mimetic and demethylating agents synergistically trigger cell death in acute myeloid leukemia cells and overcome apoptosis resistance by inducing necroptosis.

Pub. Date : 2013 Sep 12

PMID : 24030154






2 Functional Relationships(s)
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1 Importantly, BV6/DAC-induced cell death in the presence of zVAD.fmk is significantly reduced by pharmacological inhibition of key components of necroptosis signaling, that is, receptor-interacting protein (RIP) 1 using necrostatin-1 or mixed lineage kinase domain-like protein (MLKL) using necrosulfonamide. benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone mixed lineage kinase domain like pseudokinase Homo sapiens
2 Importantly, BV6/DAC-induced cell death in the presence of zVAD.fmk is significantly reduced by pharmacological inhibition of key components of necroptosis signaling, that is, receptor-interacting protein (RIP) 1 using necrostatin-1 or mixed lineage kinase domain-like protein (MLKL) using necrosulfonamide. benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone mixed lineage kinase domain like pseudokinase Homo sapiens