Title : Assessment of vandetanib as an inhibitor of various human renal transporters: inhibition of multidrug and toxin extrusion as a possible mechanism leading to decreased cisplatin and creatinine clearance.

Pub. Date : 2013 Dec

PMID : 24026623






3 Functional Relationships(s)
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1 Vandetanib was evaluated as an inhibitor of human organic anion transporter 1 (OAT1), OAT3, organic cation transporter 2 (OCT2), and multidrug and toxin extrusion (MATE1 and MATE2K) transfected (individually) into human embryonic kidney 293 cells (HEK293). vandetanib solute carrier family 22 member 2 Homo sapiens
2 Vandetanib was evaluated as an inhibitor of human organic anion transporter 1 (OAT1), OAT3, organic cation transporter 2 (OCT2), and multidrug and toxin extrusion (MATE1 and MATE2K) transfected (individually) into human embryonic kidney 293 cells (HEK293). vandetanib solute carrier family 22 member 2 Homo sapiens
3 In summary, the results show that vandetanib is a potent inhibitor of MATE1 and MATE2K (versus OCT2). vandetanib solute carrier family 22 member 2 Homo sapiens