Title : Systematic combination screening reveals synergism between rapamycin and sunitinib against human lung cancer.

Pub. Date : 2014 Jan 1

PMID : 24018642






1 Functional Relationships(s)
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1 Furthermore, sunitinib and rapamycin displayed synergistic activity against tube formation by human microvessel endothelial cells as well as outgrowth of endothelial tubes and microvessels both in vitro and in vivo, which is associated with down-regulation of VEGF secretion and HIF1alpha expression. Sirolimus vascular endothelial growth factor A Homo sapiens