Pub. Date : 2013 Nov
PMID : 24011632
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | RESULTS: The result showed that RE of gefitinib at the concentrations of 1 muM and 10 muM was 4.12 and 4.05, respectively, but significantly decreased to 1 and 1.35 after adding a P-glycoprotein (P-gp) inhibitor, cyclosporine A. | Gefitinib | phosphoglycolate phosphatase | Mus musculus |
| 2 | RESULTS: The result showed that RE of gefitinib at the concentrations of 1 muM and 10 muM was 4.12 and 4.05, respectively, but significantly decreased to 1 and 1.35 after adding a P-glycoprotein (P-gp) inhibitor, cyclosporine A. | Gefitinib | phosphoglycolate phosphatase | Mus musculus |
| 3 | CONCLUSION: Gefitinib is a P-gp substrate and has limited active BBB penetration. | Gefitinib | phosphoglycolate phosphatase | Mus musculus |