Title : Class III β-tubulin overexpression within the tumor microenvironment is a prognostic biomarker for poor overall survival in ovarian cancer patients treated with neoadjuvant carboplatin/paclitaxel.

Pub. Date : 2014 Jan

PMID : 24005572






2 Functional Relationships(s)
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1 Herein, we describe changes in class III beta-tubulin in patients with advanced ovarian carcinoma in response to NACT, in relationship to clinical outcome, and between patients who underwent NACT versus primary debulking; we characterize in vitro chemosensitivity to paclitaxel/patupilone of cell lines established from this patient population, and class III beta-tubulin expression following repeated exposure to paclitaxel. epothilone B tubulin beta 3 class III Homo sapiens
2 In vitro subculture with paclitaxel resulted in class III beta-tubulin upregulation, however, cell lines that overexpressed class III beta-tubulin remained sensitive to patupilone. epothilone B tubulin beta 3 class III Homo sapiens