Title : Long-term nicotine treatment suppresses IL-1β release and attenuates substance P- and 5-HT-evoked Ca²⁺ responses in astrocytes.

Pub. Date : 2013 Oct 11

PMID : 23994388






4 Functional Relationships(s)
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1 Long-term nicotine treatment suppresses IL-1beta release and attenuates substance P- and 5-HT-evoked Ca2+ responses in astrocytes. Nicotine interleukin 1 beta Homo sapiens
2 The aim of this study was to investigate whether short- or long-term nicotine treatment, had an influence on Ca(2+)-induced intracellular Ca(2+) release in astrocytes co-cultured with microvascular endothelial cells, and if the release of interleukin-1beta (IL-1beta) changed during this treatment. Nicotine interleukin 1 beta Homo sapiens
3 The aim of this study was to investigate whether short- or long-term nicotine treatment, had an influence on Ca(2+)-induced intracellular Ca(2+) release in astrocytes co-cultured with microvascular endothelial cells, and if the release of interleukin-1beta (IL-1beta) changed during this treatment. Nicotine interleukin 1 beta Homo sapiens
4 The results show that long-term nicotine treatment had no influence on nicotine-evoked Ca(2+) transients or protein expression of the alpha7-nAChR, but had with a decreased IL-1beta release. Nicotine interleukin 1 beta Homo sapiens