Title : The activation of RhoC in vascular endothelial cells is required for the S1P receptor type 2-induced inhibition of angiogenesis.

Pub. Date : 2013 Dec

PMID : 23993968






1 Functional Relationships(s)
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1 Furthermore, suppression of the activity of G proteins of the Galpha12/13 subfamily by adenoviral overexpression of the regulator of G protein signaling domain of LSC as well as siRNA-mediated knockdown of the Rho specific guanine nucleotide exchange factor leukemia associated RhoGEF (LARG) inhibited the S1P-induced activation of RhoC and concomitantly increased sprouting of HUVEC with similar efficacy. Guanine Nucleotides Rho guanine nucleotide exchange factor 12 Homo sapiens