Pub. Date : 2013
PMID : 23991038
9 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Luminal breast cancer cell lines overexpressing ZNF703 are resistant to tamoxifen through activation of Akt/mTOR signaling. | Tamoxifen | zinc finger protein 703 | Homo sapiens |
| 2 | Therefore, the goal of our study was to explore the role of ZNF703 in tamoxifen resistance. | Tamoxifen | zinc finger protein 703 | Homo sapiens |
| 3 | ZNF703 overexpression in MCF-7 breast cancer cells activated the Akt/mTOR signaling pathway, downregulated ERalpha, and reduced the antitumor effect of tamoxifen. | Tamoxifen | zinc finger protein 703 | Homo sapiens |
| 4 | Low-dose tamoxifen did not suppress, but rather, stimulated the growth of cells overexpressing ZNF703. | Tamoxifen | zinc finger protein 703 | Homo sapiens |
| 5 | ZNF703 knockdown in MDA-MB-134 and HCC1500 luminal B-type breast cancer cell lines by siRNA significantly decreased survival rates when cells were treated with tamoxifen. | Tamoxifen | zinc finger protein 703 | Homo sapiens |
| 6 | Furthermore, targeting ZNF703 with a mTOR inhibitor increased the inhibitory effects of tamoxifen in ZNF703-overexpressing cells. | Tamoxifen | zinc finger protein 703 | Homo sapiens |
| 7 | Furthermore, targeting ZNF703 with a mTOR inhibitor increased the inhibitory effects of tamoxifen in ZNF703-overexpressing cells. | Tamoxifen | zinc finger protein 703 | Homo sapiens |
| 8 | CONCLUSION/SIGNIFICANCE: Our study suggests that ZNF703 expression levels may predict tamoxifen sensitivity. | Tamoxifen | zinc finger protein 703 | Homo sapiens |
| 9 | Tamoxifen should be administered with caution to those patients bearing tumors with ZNF703 overexpression. | Tamoxifen | zinc finger protein 703 | Homo sapiens |