Title : Probucol inhibits JAK2-STAT pathway activation and protects human glomerular mesangial cells from tert-butyl hydroperoxide induced premature senescence.

Pub. Date : 2013 Sep

PMID : 23984931






2 Functional Relationships(s)
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1 After tBHP treatment, Bcl-2 protein expression decreased and Bax protein expression increased. tert-Butylhydroperoxide BCL2 associated X, apoptosis regulator Homo sapiens
2 Our results indicated that the JAK2-STAT pathway might mediate tBHP-induced HMC senescence through the Bcl-2-Bax pathway, and that probucol could attenuate HMC senescence by regulating STATs. tert-Butylhydroperoxide BCL2 associated X, apoptosis regulator Homo sapiens