Pub. Date : 2013 Oct 9
PMID : 23968725
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Arsenite-induced HIF-1alpha, VEGF and COX-2 expressions were decreased by PI3K inhibitors. | arsenite | vascular endothelial growth factor A | Homo sapiens |
| 2 | Blockage of the ERK1/2, p38 and JNK down-regulated the VEGF level, while ERK1/2 and p38 inhibitors were more effective than JNK in attenuating arsenite-induced COX-2 expression. | arsenite | vascular endothelial growth factor A | Homo sapiens |
| 3 | It was found that superoxide (O2(-)) generation was involved in arsenite-induced the activation of MAPK and PI3K pathways, which led to the HIF-1alpha, COX-2 and VEGF overexpressions. | arsenite | vascular endothelial growth factor A | Homo sapiens |
| 4 | In conclusion, arsenite-induced COX-2, VEGF and HIF-1alpha expressions, mediated partially by reactive oxygen species (ROS), were regulated by MAPK and PI3K/AKT signaling pathways in human uroepithelial cells. | arsenite | vascular endothelial growth factor A | Homo sapiens |