Title : Grape seed procyanidin reversal of p-glycoprotein associated multi-drug resistance via down-regulation of NF-κB and MAPK/ERK mediated YB-1 activity in A2780/T cells.

Pub. Date : 2013

PMID : 23967153






2 Functional Relationships(s)
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1 Grape seed procyanidin(GSP) is a natural polyphenol supplement with anti-inflammatory effect. Polyphenols GSM1 Homo sapiens
2 Thus, GSP reverses P-gp associated MDR by inhibiting the function and expression of P-gp through down-regulation of NF-kappaB activity and MAPK/ERK pathway mediated YB-1 nuclear translocation, offering insight into the mechanism of reversing MDR by natural polyphenol supplement compounds. Polyphenols GSM1 Homo sapiens