Pub. Date : 2013 Aug
PMID : 23963659
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | This previously unrecognized long-term effect of sorafenib was mediated by AMPK-dependent inhibition of the mTORC1 pathway. | Sorafenib | CREB regulated transcription coactivator 1 | Mus musculus |
| 2 | Suppression of mTORC1 activity was sufficient for sorafenib to hinder glucose utilization in breast cancer cells, as demonstrated by the observation that the mTORC1 inhibitor rapamycin induced a comparable down-regulation of GLUT-1 expression and glucose uptake. | Sorafenib | CREB regulated transcription coactivator 1 | Mus musculus |
| 3 | Suppression of mTORC1 activity was sufficient for sorafenib to hinder glucose utilization in breast cancer cells, as demonstrated by the observation that the mTORC1 inhibitor rapamycin induced a comparable down-regulation of GLUT-1 expression and glucose uptake. | Sorafenib | CREB regulated transcription coactivator 1 | Mus musculus |
| 4 | The key role of AMPK-dependent inhibition of mTORC1 in sorafenib mechanisms of action was confirmed by AMPKalpha1 silencing, which restored mTORC1 activity conferring a significant protection from cell death. | Sorafenib | CREB regulated transcription coactivator 1 | Mus musculus |
| 5 | The key role of AMPK-dependent inhibition of mTORC1 in sorafenib mechanisms of action was confirmed by AMPKalpha1 silencing, which restored mTORC1 activity conferring a significant protection from cell death. | Sorafenib | CREB regulated transcription coactivator 1 | Mus musculus |