Title : Sorafenib overcomes irinotecan resistance in colorectal cancer by inhibiting the ABCG2 drug-efflux pump.

Pub. Date : 2013 Oct

PMID : 23960095






1 Functional Relationships(s)
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1 We have shown that sorafenib improved the antitumoral activity of irinotecan in vitro, in both parental and SN-38-resistant colon adenocarcinoma cell lines independently of their KRAS status, as well as in vivo, in xenografted mice. Sorafenib Kirsten rat sarcoma viral oncogene homolog Mus musculus