Title : Structure-based mechanism for early PLP-mediated steps of rabbit cytosolic serine hydroxymethyltransferase reaction.

Pub. Date : 2013

PMID : 23956983






1 Functional Relationships(s)
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1 The kinetic and crystallographic data acquired with mutant enzymes permit us to infer that conversion of gem-diamine to external aldimine is significantly slowed because intermediates are trapped into an anomalous position by a misorientation of the PLP ring, and a new energy barrier hampers the transaldimination reaction. gem-diamine myelin proteolipid protein Oryctolagus cuniculus