Title : Inhibition of PPARĪ± induces cell cycle arrest and apoptosis, and synergizes with glycolysis inhibition in kidney cancer cells.

Pub. Date : 2013

PMID : 23951092






1 Functional Relationships(s)
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1 A specific PPARalpha antagonist, GW6471, induced both apoptosis and cell cycle arrest at G0/G1 in VHL(+) and VHL(-) RCC cell lines (786-O and Caki-1) associated with attenuation of the cell cycle regulatory proteins c-Myc, Cyclin D1, and CDK4; this data was confirmed as specific to PPARalpha antagonism by siRNA methods. GW 6471 cyclin D1 Homo sapiens