Title : Lapatinib sensitivities of two novel trastuzumab-resistant HER2 gene-amplified gastric cancer cell lines.

Pub. Date : 2014

PMID : 23948998






1 Functional Relationships(s)
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1 This growth inhibition of the Tmab-resistant cells by lapatinib was due to both G1 cell-cycle arrest and apoptosis induction via effective blockade of the PI3K/Akt and MAPK pathways. Lapatinib AKT serine/threonine kinase 1 Homo sapiens