Pub. Date : 2013 Oct
PMID : 23943804
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Evidence indicates that the mechanism of this synergy includes reactivation of miR-200a, which targets and destabilizes kelch-like ECH-associated protein 1 (KEAP1) mRNA, resulting in the translocation and binding of nuclear factor (erythroid-derived 2)-like 2 (NRF2) to the polyamine-responsive element of the SSAT promoter. | Polyamines | spermidine/spermine N1-acetyltransferase 1 | Homo sapiens |
| 2 | This transcriptional stimulation, combined with positive regulation of SSAT mRNA and protein by the analogs, results in decreased intracellular concentrations of natural polyamines and growth inhibition. | Polyamines | spermidine/spermine N1-acetyltransferase 1 | Homo sapiens |